Since I do work on Drupal sites from time to time and have built some very large ones I do keep an eye on the Drupal "stack" and change. But, I haven't revisted it for a while.
A few months ago I posted an article about a Drupal stack that I had tested w/ a big media company to do 2.5 billion page views a a month. It was a lot of servers and some sophisticated modifications to Drupal.
It's still a solid architecture but there are some new entries I thought I'd like to evaluate. I also deployed that one on Joyent so I was curious what I might be able to do with other cloud vendors. This time I picked Rackspace's Cloud Servers since they were kind enough to comp. nScaled, Inc. a little free time to test things out an demo to clients. So, I've been beating up on them pretty good. I'm impressed and considering what I did to some of their servers yesterday I'm surprised I didn't get a cease and desist!
Here is the Drupal Stack I built and configured.